Merck Serono Thyroid History

In 1894, E. Merck introduced one of the first thyroid preparations in the world. Since then, E. Merck has played a substantial role in thyroid research and development:
1894
Thyroidinum siccatum
Introduction of desiccated sheep thyroid gland (powder, later tablets) in Germany. Available as Thyroidin Merck until 1983
1896
Thyroidin Merck (USA)
Offered in the price list published in Merck's 1896 Index (New York)
1901
Antithyroidin Merck
Produced from the serum of thyroidectomized rams (Moebius)
1911
Glandula Thyroideae siccata "Merck" Tabletten
Desiccated thyroid gland available as tablets
1912
Research on a standardized thyroid extract product
(Annual report Scientific Laboratory 1912)
1921
Thyreoidinum depurat. Notkin Tabletten
Thyroid protein extract
1925
Evaluation of Kendall's Thyroxine
"Obviously thyroxine is not the only active thyroid product"
1925
Thyroidea Opton
Introduction of protein-free degradation product of the thyroid gland
1928
Novothyral
Introduction of water soluble standardized thyroid extract (Axolotl)
1941
Thyroidin Merck
Standardized also with Axolotl method
1948
Methicil
Brand of Methylthiouracil available from Merck in Germany
1965
Kalium jodatum Compretten (100 mg KI)
Indicated for prevention of radioactive iodine incorporation in nuclear accidents
1968
Novothyral
Newly introduced as a T4/T3 combination in Germany
1973
Euthyrox
Mono T4 tablets introduced in Germany, later in many other countries
1975
Jodid Merck
Iodide 100 µg tablets (later 200 and 500 µg) introduced in Germany
1985
Jodthyrox
T4/Iodide combination introduced in Germany for iodine deficiency goiter
1990
Thyrozol
Thiamazole (Methimazole) introduced in Germany
1993
Beginning globalization of Merck thyroid business
1995
Merck KGaA a cooperation with several partners was founded
2007
Establishing Merck Serono following the acquisition of Serono by Merck KGaA
The thyroid products of Merck Serono , are now marketed all over the world, from France to Vietnam, from Russia to Chile. The most important product is Euthyrox (Eutirox, Lévothyrox) which is a levothyroxine (T4) monopreparation. Other regionally sold products are T4/T3 combinations, iodide, a T4/iodide combination and methimazole (thiamazole).
 
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